Ungakhulelwa kanjani ngokushesha ku-metformin? .
Ama-gynecologists asebenzisa i-metformin njengengxenye yokwelashwa ukukhulelwa; sikutshela kanjani:
IMetformin yokukhulelwa
Abesifazane abane ukumelana ne-insulin ingahle ibe nokuhlukahluka Izinkinga zabesifazane , kufaka phakathi ubunzima bokukhulelwa. Ngakho-ke, odokotela besifazane bazindla nge-metformin ukusiza owesifazane ukulawula ukumelana ne-insulin futhi ngaleyo ndlela agcine umjikelezo owanele wokuya esikhathini futhi athole ukukhulelwa.
I-Metformin ayiyona leyo ndlela yokwelashwa kokuzala , kepha kusiza ukulawula umjikelezo wokuya esikhathini wabesifazane abathintekayo ukumelana ne-insulin futhi kanjalo kuzuzwe ukukhulelwa kalula . Futhi, uma owesifazane elawula ukumelana ne-insulin yakhe, ngeke akhulelwe kuphela kepha uzonciphisa kakhulu ingozi yokulahlekelwa ngumntwana ezinyangeni ezilandelayo zokukhulelwa.
Lapho owesifazane esekwazi ukulinganisela isimo sakhe se-hormonal, kukhombisa uDokotela Wangaphakathi uJosé Víctor Manuel Rincón Ponce, waseMexico Social Security Institute, imijikelezo yakhe yokuya esikhathini nayo yenziwe njalo, futhi ngalokho kuzoba lula ukwenza indawo efanelekile yomzimba wakhe une futhi ugcine ukukhulelwa kwesikhathi esigcwele.
Ukuthola ukukhulelwa okuphethwe yi-polycystic ovary syndrome
I-Polycystic ovary syndrome, ukuphazamiseka okubonakala ngama-mens angajwayelekile, ukuguqulwa kwe-hormonal, kanye nokuvela kwama-cysts amaningi kuma-ovari, kuthinta cishe i-8% yabantu besifazane. Okudala le nkinga kusenokungabaza, futhi ukuxilongwa nokwelashwa kuxoxwe kakhulu ngakho.
Okwaziwayo ukuthi lesi ngesinye sezizathu eziyinhloko zokuzala kwabesifazane, lapho ungangeza khona ezinye izinkinga zomzimba, njengokukhuluphala noma ukumelana ne-insulin.
Ucwaningo olwenziwe yiqembu labacwaningi abavela emanyuvesi ahlukene aseMelika, ukuze kuqinisekiswe imiphumela yezifundo ezincane ku indlela engcono kakhulu yokwelapha ukungabi nenzalo kwabesifazane abane-polycystic ovarian syndrome , futhi esishicilelwe kumagazini iThe New England England of Medicine, sichaza ukuthi umuthi wakudala owawusetshenziselwa ukukhuthaza ukukhiqizwa kweqanda ngokusebenza kwawo kwihomoni ekhuthaza ubuhlanga, i-clomiphene citrate, iyindlela engcono kakhulu kwabesifazane abahlushwa yilesi sifo ukuthi bakhulelwe , futhi iyindlela elula, eshibhile, ephephile nesebenzayo.
Ukusetshenziswa kwakamuva kwakungu-metformin, umuthi osetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo lwe-2, okwathi ngokwenza ngcono i-glucose nokukhuluphala kukhuthaze ukukhulelwa. Ucwaningo lwenziwa nabesifazane abangama-626 abangenanzalo ngenxa yalesi sifo futhi babasabalalisa ngamaqembu amathathu, iqembu elilodwa lathola umuthi olwa nesifo sikashukela (i-metformin ekhishwe isikhathi eside), elinye i-inducer ye-ovulation (i-clomiphene citrate) kanti owesithathu wathola inhlanganisela yomibili imishanguzo . Ukwelashwa nokulandelwa kuhlale isikhathi esingaphezu kwamasonto angama-30 noma baze bathola ukukhulelwa.
Ekupheleni kocwaningo, abesifazane ababethole i-clomiphene babonisa isilinganiso sokuzalwa esiphindwe kathathu kunaleso seqembu le-metformin; ngaphezu kwalokho, owokuqala wayenenani eliphakeme lokukhulelwa okuningi.
Labo abathathe inhlanganisela yomibili yezidakamizwa bakhombisa isilinganiso se-ovulation esiphakeme kunaleso sonke, kepha ukuzalwa akuzange kugcwaliseke, yize kwafanisa ukukhulelwa okuningi neqembu elathola i-ovulation inducer.
Ucwaningo lwangaphambilini lwalusikisele okuphambene nalokhu, kepha umphumela awuzange uhlaziywe lapho kuzalwa, kepha ngesilinganiso se-ovulation, okungesona isifiso sabesifazane abaphethwe yilesi sifo.
Izinkomba:
Ijenali Buka Imininingwane engaphezulu
- IBarbieri RL, et al. (2017). I-Metformin yokwelashwa kwe-polycystic ovary syndrome.
uptodate.com/contents/metformin-for-treatment-of-the-polycystic-ovary-syndrome - Zibophezele ekukhetheni okunempilo ukusiza ukuvimbela ukukhubazeka kokuzalwa. (2017).
cdc.gov/ncbddd/birthdefects/prevention.html - UFeig DS, et al. (2011). Ukwelashwa kweMetformin ngesikhathi sokukhulelwa. INGABE:
doi.org/10.2337/dc11-1153 - Amaphilisi e-Glucophage (metformin hydrochloride); I-Glucophage XR (metformin hydrochloride) amaphilisi akhululwa. (2017).
accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf - Abasebenzi baseMayo Clinic. (2017). Isifo sikashukela sokukhulelwa.
mayoclinic.org/diseases-conditions/gestational-diabetes/basics/risk-factors/con-20014854
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