I-Tribedoce iqukethe uvithamini B1 (thiamine hydrochloride) , uvithamini B12 (hydroxocobalamin) , uvithamini B6 (pyridoxine hydrochloride) . Inomphumela omuhle ekusebenzeni kwesibindi nakuhlelo lwezinzwa. Kusebenza ukujiya kwegazi ngemithamo ephezulu kudala ukwanda komsebenzi we-thromboplastin ne-prothrombin.
Isenzo semithi
Tribedoce) kubhekiswa eqenjini lamavithamini ancibilika emanzini. Inomsebenzi ophakeme wezinto eziphilayo. I-Tribedoce (i-vitamin B12 (i-hydroxocobalamin)) iyadingeka ku-hematopoiesis ejwayelekile (ikhuthaza ukuvuthwa kwamangqamuzana egazi abomvu).
Ubamba iqhaza ezinhlelweni zokudluliswa, ukuthuthwa kwe-hydrogen, ukuhlanganiswa kwe-methionine, i-nucleic acid, i-choline, i-creatine. Iyasiza ekuqongeleleni kwama-erythrocyte ezinhlanganisela eziqukethe amaqembu e-sulfhydryl.
I-Pharmacokinetics
Ngemuva kokuphathwa ngomlomo, i-Tribedoce (i-vitamin B12 (i-hydroxocobalamin)) ifakwa emgodini wamathumbu. Umzimba owenziwe izicubu, ube uhlobo lwe-coenzyme - adenosylcobalamin, okuyindlela esebenzayo ye-cyanocobalamin. Ikhishwe nge-bile nomchamo.
Kungani iTribedoce) ibekiwe?
I-anemia ngenxa yezimo zokushoda ze-B12; ekwelashweni okuyinkimbinkimbi kwe-iron ne-post-hemorrhagic anemia; i-aplastic anemia ebangelwa izinto ezinobuthi nezidakamizwa; isifo sesibindi (hepatitis, cirrhosis); i-myelosis ehlekisayo; i-polyneuritis, i-radiculitis, i-neuralgia, i-amyotrophic lateral sclerosis; usana lobuchopho obukhubazekile, i-Down syndrome, ukulimala kwemizwa yezinzwa; izifo zesikhumba (i-psoriasis, i-photodermatosis, i-dermatitis herpetiformis, i-neurodermatitis); ukuvimbela nokwelapha izimpawu zokushoda kwe-Tribedoce (vitamin B12 (hydroxocobalamin)) (kufaka phakathi ukusetshenziswa kwe-biguanide, i-PASA, i-vitamin C ngemithamo ephezulu); ukugula ngemisebe.
Isikali nokuphathwa
I-Tribedoce) isetshenziswa njenge-SC, IV, IM, intralumbar kanye nomjovo womlomo. Nge-anemia ehambisana nokushoda kwe-Tribedoce (vitamin B12 (hydroxocobalamin)) yethulwa ku-100-200 mcg ezinsukwini ezimbili.
Ku-anemia enezimpawu ze-funicular myelosis kanye ne-megalocytic anemia enezifo ze- isimiso sezinzwa: Ama-microgram angu-400-500 ezinsukwini zokuqala eziyi-7 ngosuku, bese kuba isikhathi esingu-1 njalo ezinsukwini ezingama-5-7.
Esikhathini sokuxolelwa lapho ingekho imicimbi yesondlo yesilinganiso se-funicular myelosis - 100 mcg izikhathi ezi-2 ngenyanga, lapho kunezimpawu zezinzwa - kuya ku-200-400 mcg izikhathi ezi-2-4 ngenyanga.
Ngo anemia post-hemorrhagic oyingozi kanye ne-iron anemia kuma-30-100 mcg izikhathi ezingama-2-3 ngesonto. Lapho i-aplastic anemia (ikakhulukazi ezinganeni) - ama-micrograms ayi-100 ngaphambi kokuthuthuka komtholampilo.
Lapho i-anemia enomsoco ezinganeni nasezinsaneni ezizalwe ngaphambi kwesikhathi - 30 mcg / ngosuku izinsuku eziyi-15.
Ezigulini zesistimu yezinzwa emaphakathi nepheripherali kanye nezifo zemizwa ezinesifo esibuhlungu kulawulwa ngamanani akhulayo - 200-500 mcg, ngokuthuthuka kuhulumeni - 100 mcg / ngosuku.
Inkambo yokwelashwa nge-Tribedoce (i-vitamin B12 (i-hydroxocobalamin)) ngamaviki ama-2. Ezilondeni ezihlukumezayo zesistimu ye-peripheral nervous: ku-200-400 mcg zonke izinsuku ezinye izinsuku ezingama-40-45.
Lapho i-hepatitis ne-cirrhosis: 30-60 mcg / usuku noma i-100 mg nsuku zonke ezinye izinsuku ezingama-25-40.
I-Dystrophy ezinganeni ezincane, i-Down syndrome ne-cerebral palsy: ngo-15-30 mcg zonke izinsuku.
Lapho i-funicular myelosis, i-amyotrophic lateral sclerosis ingeniswa emgodini womgogodla ku-15-30 mcg, ikhuphule kancane umthamo wama-micrograms angama-200-250.
Ekuguleni kwemisebe, isifo sikashukela se-neuropathy, sikhuphuka kuma-60-100 mcg nsuku zonke izinsuku ezingama-20-30.
Lapho ukwehluleka kweTribedoce (Vitamin B12 (Hydroxocobalamin)) ukuvimbela - IV noma i-IM 1 mg 1 isikhathi ngenyanga; ekwelashweni: IV noma i-IM nge-1 mg ngosuku ngamaviki ayi-1-2, umthamo wesondlo uyi-1-2 mg IV noma i-IM nge-1 ngeviki, kuze kufike ku-1 ngenyanga. Isikhathi sokwelashwa sinqunywa ngamunye.
isikhangiso
Tribe nambili imiphumela emibi, ukusabela ezingezinhle
I-CNS: kuyaqabukela, isimo senjabulo.
Isistimu yenhliziyo: akuvamile - ubuhlungu enhliziyweni, i-tachycardia.
Ukungezwani komzimba: kuyaqabukela - isifuba.
Tribedoce) ukuphikisana
I-Thromboembolism, i-erythremia, i-erythrocytosis, ukwanda kokuzwela kwe-cyanocobalamin.
Tribedoce) ngesikhathi sokukhulelwa kanye ne-lactation
I-cyanocobalamin ingasetshenziswa ekukhulelweni ngokusho kwezindlela zokupheka.
Imiyalo ekhethekile
Lapho i-stenocardia kufanele isetshenziswe ngokuqapha kumthamo owodwa we-Tribedoce) 100 mcg. Ukucabanga ngegazi kanye ne-coagulation kufanele kuhlolwe njalo ngesikhathi sokwelashwa. Akwamukelekile ukufaka isirinji efanayo nezixazululo ze-thiamine ne-pyridoxine cyanocobalamin.
Isizwe ukuxhumana okuyishumi nambili
Ekusetshenzisweni kweTribedoce (Vitamin B12 (Hydroxocobalamin)) enezindlela zokuvimbela inzalo zamahomoni ekuphathweni ngomlomo kunganciphisa ukugxila kwe-cyanocobalamin ku-plasma.
Ekusebenziseni ngemithi elwa ne-anticonvulsant, ukumuncwa kwe-cyanocobalamin ngamathumbu kwehlisiwe.
Ekusetshenzisweni kweTribedoce (Vitamin B12 (Hydroxocobalamin)) neomycin, aminosalicylic acid, colchicine, cimetidine, ranitidine, izidakamizwa ze-potassium zinciphise ukumuncwa kwe-cyanocobalamin emathunjini.
I-cyanocobalamin ingakhuphula ukungezwani komzimba okubangelwa yi-thiamine.
Lapho ukusetshenziswa kwabazali kwe-chloramphenicol kunganciphisa imiphumela ye-hematopoietic ye-cyanocobalamin ene-anemia.
Ukungahambelani kwemithi
Okuqukethwe i-cobalt ion molecule ye-cyanocobalamin kunomthelela ekubhujisweni kwe-ascorbic acid, i-thiamine bromide, i-riboflavin kusixazululo.
isikhangiso
Izithako ezisebenzayo zemithi ye-Tribedoce equkethe igama lomkhiqizo nemithi ejwayelekile ehlobene:
Isithako esisebenzayo yingxenye yesidakamizwa noma isidakamizwa esisebenza ngokuphila. Le ngxenye yomuthi ibhekele isenzo esiyinhloko somuthi ohloselwe ukwelapha noma ukunciphisa uphawu noma isifo. Ezinye izingxenye zomuthi ezingasebenzi zibizwa ngokuthi ama-excipients; Indima yalo ukwenza njengemoto noma isibopho. Ngokungafani nesithako esisebenzayo, indima yesithako esingasebenzi ayibalulekile ekwelapheni noma ekwelapheni lesi sifo. Kungaba nesithako esisodwa noma eziningi ezisebenzayo kumuthi.
- Uvithamini B1 (thiamine hydrochloride)
- Uvithamini B12 (hydroxocobalamin)
- Uvithamini B6 (pyridoxine hydrochloride)
Izinkampani ezithaka imithi eziyishumi nambili:
Izinkampani ezenza imithi yizinkampani ezikhiqiza izidakamizwa ezisiza ekwakhiweni okuphelele komuthi, kusuka ocwaningweni lwangemuva kuya ekuqeqeshweni, ekuhlolweni kwemitholampilo, ekukhishweni kwezidakamizwa kuya emakethe, nasekuthengisweni kwezidakamizwa.
Abaphenyi ngabantu ababhekele ucwaningo lwesayensi nakho konke ukuhlolwa kwangaphambilini komtholampilo okuholele ekwakhiweni komuthi.
Imibuzo ejwayelekile
Ngingakwazi yini ukushayela noma ukusebenzisa imishini esindayo ngemuva kokuthatha iTribedoce?
Ngokuya ngokusabela kweTribedoce ngemuva kokuyithatha, uma uzizwa unesiyezi, ukozela noma yikuphi ukusabela okubuthakathaka emzimbeni wakho, bese ubheka ukuthi iTribedoce ayiphephile ukushayela noma ukusebenzisa imishini esindayo ngemuva kokuyisebenzisa.
Okusho ukuthi ungashayeli noma usebenzise imishini esindayo ngemuva kokuthatha i-capsule uma ngabe i-capsule inokusabela okungajwayelekile emzimbeni wakho njengesizungu, ukozela. Njengoba kushiwo ngusokhemisi, kuyingozi ukuphuza utshwala ngenkathi uthatha imishanguzo njengoba kuveza iziguli ukozela kanye nengozi yezempilo.
Wazi lo mphumela, ikakhulukazi lapho uthatha i-Primosa capsule. Kungakuhle uthintane nodokotela wakho ngesikhathi ukuze uthole izincomo ezifanele kanye nokubonisana nabezempilo. Ingabe iTribedoce iyalutha noma ijwayele ukwakha?
Izidakamizwa azenzelwanga ngenhloso yokwakha ukuluthwa noma ukuhlukunyezwa empilweni yabasebenzisi. Umuthi wokulutha ubizwa ngokweqile ngokuthi izinto ezilawulwa nguhulumeni. Isibonelo, uHlelo H noma u-X eNdiya kanye noHlelo II-V e-United States yizinto ezilawulwayo.
Bheka ibhukwana lokufundisa lomuthi ukuthi ulisebenzisa kanjani futhi uqiniseke ukuthi akuyona into elawulwayo. Ekuphetheni, ukuzelapha ngokwakho kuyingozi empilweni yakho. Xhumana nodokotela wakho ukuthola incwadi kadokotela efanele, izincomo kanye nokuholwa.
Ukweqisa ngokweqile
Uma umuntu eyeqile futhi enezimpawu ezinzima njengokuquleka noma ukuphefumula okuncane, shayela ku-911. Ngaphandle kwalokho, shayela isikhungo sokulawula ubuthi ngokushesha. Izakhamizi zase-United States zingashayela isikhungo sendawo sabo sokulawula ubuthi ku 1-800-222-1222 . Izakhamizi zaseCanada zingashayela isikhungo esilawula ubuthi esifundazweni. Izimpawu zokudlula ngokweqile zingafaka: ukuquleka.
Amanothi
Ungahlanganyeli lo muthi nabanye. Ukuhlolwa kwelabhorethri kanye / noma kwezokwelapha (njengokubala okuphelele kwegazi, ukuhlolwa kwezinso) kufanele kwenziwe ngenkathi usebenzisa lo muthi. Gcina konke ukuqokwa kwezokwelapha kanye nelabhorethri.
Isitoreji
Thintana nemiyalo yomkhiqizo kanye nosokhemisi wakho ngemininingwane yokugcina. Gcina yonke imishanguzo ezingafinyeleli ezinganeni nasezilwaneni ezifuywayo, ungafaki imishanguzo ethoyilethi noma uyithululele edreyini ngaphandle uma uyaliwe. Lahla kahle lo mkhiqizo uma usuphelelwe yisikhathi noma ungasadingeki. Thintana nosokhemisi wakho noma inkampani yangakini yokulahla imfucuza.
Ukuzikhulula: ONgqongqoshe benze yonke imizamo yokuqinisekisa ukuthi yonke imininingwane ilungile, iphelele futhi isesikhathini. Kodwa-ke, le ndatshana akufanele isetshenziswe njengokungena esikhundleni solwazi nesipiliyoni sochwepheshe wezokunakekelwa kwezempilo onelayisense. Kufanele uhlale uthintana nodokotela wakho noma omunye uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuthatha noma imuphi umuthi.
Imininingwane yezidakamizwa equkethwe lapha ingashintsha futhi ayihloselwe ukumboza konke ukusetshenziswa okungaba khona, imiyalelo, izixwayiso, izexwayiso, ukuxhumana kwezidakamizwa, ukungezwani komzimba, noma imiphumela emibi. Ukungabikho kwezixwayiso noma olunye ulwazi lomuthi othile akubonisi ukuthi inhlanganisela yezidakamizwa noma yezidakamizwa iphephile, iyasebenza, noma ilungele zonke iziguli noma konke ukusetshenziswa okuthile.
Izikhombisi
- I-DailyMed. I-ASCORBIC ACID; IBIOTIN; CHOLECALCIFEROL; ICYANOCOBALAMIN; DEXPANTHENOL; I-ACID YOKUGCINA; NIACINAMIDE; I-PYRIDOXINE; RIBOFLAVIN; THIAMINE; TOCOPHEROL ACETATE; IVITAMIN A; IVITAMIN K: IDailyMed inikeza imininingwane ethembekile ngemithi emakethwa e-United States. IDailyMed ingumhlinzeki osemthethweni wemininingwane yelebula le-FDA (ukufakwa kwephakeji) .. https://dailymed.nlm.nih.gov/dailyme… (kufinyelelwe ngoSepthemba 17, 2018).
- I-DailyMed. I-DICLOFENAC EPOLAMINE: IDailyMed inikeza imininingwane ethembekile ngemithi emakethwa e-United States. IDailyMed ingumhlinzeki osemthethweni wemininingwane yelebula le-FDA (ukufakwa kwephakeji) .. https://dailymed.nlm.nih.gov/dailyme… (kufinyelelwe ngoSepthemba 17, 2018).
- I-PubChem. lindokuhle. https://pubchem.ncbi.nlm.nih.gov/com… (kufinyelelwe ngoSepthemba 17, 2018).
- I-PubChem. thiamine. https://pubchem.ncbi.nlm.nih.gov/com… (kufinyelelwe ngoSepthemba 17, 2018).
- I-PubChem. umagazine. https://pubchem.ncbi.nlm.nih.gov/com… (kufinyelelwe ngoSepthemba 17, 2018)
Okuqukethwe
- Isenzo semithi
- I-Pharmacokinetics
- Kungani iTribedoce) ibekiwe?
- Isikali nokuphathwa
- Tribe nambili imiphumela emibi, ukusabela ezingezinhle
- Tribedoce) ukuphikisana
- Tribedoce) ngesikhathi sokukhulelwa kanye ne-lactation
- Imiyalo ekhethekile
- Isizwe ukuxhumana okuyishumi nambili
- Izithako ezisebenzayo zemithi ye-Tribedoce equkethe igama lomkhiqizo nemithi ejwayelekile ehlobene:
- Izinkampani ezithaka imithi eziyishumi nambili:
- Imibuzo ejwayelekile
- Ukweqisa ngokweqile
- Amanothi
- Isitoreji
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